CELL-SPECIFIC MODELS OF HIPSC-CMS DEVELOPED BY THE GRADIENT-BASED PARAMETER OPTIMIZATION METHOD FITTING TWO DIFFERENT ACTION POTENTIAL WAVEFORMS

Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms

Abstract Parameter optimization (PO) methods to determine the ionic current composition of experimental cardiac action potential (AP) waveform have been developed using a computer model of cardiac membrane excitation.However, it was suggested that fitting Round Baker a single AP record in the PO method was not always successful in providing a uniqu

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Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

The retinal pigment epithelium (RPE) is the primary site of injury in Parts non-neovascular age-related macular degeneration or dry AMD.Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated variants is not well understood.Here, we highlig

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Shifting from Fragmentation to Integration: A Systematic Analysis of Long-Term Care Insurance Policies in China

Introduction: Long-term care is an effective intervention that help older people cope with significant declines in capacity.The growing demand for long-term care signals a new social risk and has been given a higher political priority in China.In 2016, 15 local authorities have been selected to pilot the long-term care insurance programme.However,

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New record of Pelecitus sp. (Nematoda, Onchocercidae) as a parasite of Athene cunicularia (Strigiformes, Strigidae) in southeastern Brazil

The aim of this study Sunglasses was to report the burrowing owl Athene cunicularia as a new host for the filarid nematode Pelecitus sp.in southeastern Brazil for the first time, as well as reporting the occurrence of this nematode species in the body cavity, near the cervical air sac and lung region.This study contributes towards GRASS FED BUTTER

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